1.Suppose we want to design a new placebo-controlled trialto evaluate an experim

1.Suppose we want to design a new placebo-controlled trialto evaluate an experimental medication to increase lungcapacity. The primary outcome is peak expiratory flow rate acontinuous variable measured in liters per minute. Theprimary outcome will be measured after 6 months on treatment.The expected peak expiratory flow rate in adults is 300 with astandard deviation of 50. How many subjects should be enrolled toensure 80% power to detect a difference of 15 liters per minutewith a two sided test and a=0.05?